Based on limited published evidence, CD300H is an immunoglobulin-like receptor involved in innate immunity. It associates with signaling adaptors DAP12 and DAP10, and is expressed on CD16+ monocytes and myeloid dendritic cells 1. CD300H ligation induces production of neutrophil chemoattractants, facilitating recruitment of circulating monocytes and neutrophils to infection sites 1. The gene exhibits functional polymorphism, with a splice site SNP (rs905709) causing variable expression among populations, potentially affecting innate immune responses 1.
No tissue expression data available for this gene.