CDC42BPA (CDC42 binding protein kinase alpha) is a serine/threonine kinase serving as a critical downstream effector of the small GTPase CDC42 1. Its primary function involves regulating cytoskeletal reorganization and cell migration through phosphorylation of key substrates including PPP1R12C, MYL9, LIMK1, and LIMK2, thereby controlling actin dynamics at the lamellipodium and cell leading edge 2. CDC42BPA coordinates with MYO18A and LURAP1 to modulate actomyosin retrograde flow essential for cell protrusion 2. Disease relevance spans multiple pathologies. In colon cancer, CDC42BPA expression correlates directly with invasive capacity and metastatic potential; elevated expression promotes epithelial-mesenchymal transition and predicts poor patient survival 1. In colorectal cancer, miR-29a-3p suppresses CDC42BPA expression to inhibit cell migration and invasion 3. CDC42BPA expression is dysregulated in schizophrenia, with 33% elevation in dorsolateral prefrontal cortex, though functional correlation with dendritic pathology remains unclear 4. Genetic variants in CDC42BPA (rs3000811) associate with non-obstructive azoospermia and germ cell maturation arrest in male infertility 5. CDC42BPA also emerges as a metabolism-related gene with predictive power in idiopathic pulmonary arterial hypertension 6. Clinically, CDC42BPA represents a potential therapeutic target for metastatic cancers and a prognostic biomarker for patient stratification in colon cancer.