LURAP1 (leucine rich adaptor protein 1) is a multifunctional adaptor protein with roles in immune regulation and cytoskeletal dynamics. Primarily, LURAP1 acts as an activator of the canonical NF-κB pathway, driving pro-inflammatory cytokine production and enhancing dendritic cell antigen-presenting and priming functions 1. Mechanistically, LURAP1 operates through two distinct pathways: (1) it coordinates with MYO18A and MRCK to modulate lamellar actomyosin retrograde flow through CDC42BPA/CDC42BPB activation, promoting cell protrusion and migration 2; and (2) it interacts with Dishevelled to regulate Wnt/PCP signaling during gastrulation, controlling cellular polarization and directional movement 3. Additionally, LURAP1 coordinates actomyosin and microtubule networks through phosphorylation-dependent regulation with CLASP2, facilitating efficient cell migration 4. In skeletal muscle, LURAP1 associates with MYO18A to maintain myofiber integrity and proper dystrophin localization at the sarcolemma 5. Disease relevance includes potential roles in B-cell differentiation within lymphoma microenvironments, where LURAP1 was identified as a hub gene influenced by intratumoral microbiome in diffuse large B-cell lymphoma 6. These findings suggest LURAP1 functions as a critical integration point for immune signaling, cytoskeletal organization, and developmental morphogenesis.