MYO18A (myosin XVIIIA) is a structural myosin that lacks active ATPase-driven motor activity, functioning instead as an organizing protein in diverse cellular compartments 1. At the trans-Golgi network, MYO18A complexes with GOLPH3 to promote vesicle budding and facilitate Golgi-to-plasma membrane trafficking 2. The protein also participates in a complex with LURAP1 and MRCK that regulates retrograde actin treadmilling crucial for cell migration and protrusion 2. In immune regulation, MYO18A suppresses macrophage inflammatory responses by modulating CD14 trafficking and serves as a receptor for surfactant-associated protein A, enabling clearance of opsonized pathogens 3. Additionally, MYO18A enhances natural killer cell cytotoxicity and is involved in innate immune receptor trafficking on macrophages 4. Dysregulation of MYO18A is associated with multiple diseases: its fusion with FGFR1 occurs in myeloproliferative neoplasms 5, elevated serum levels correlate with poor prognosis in acute myeloid leukemia 6, and it functions in cholangiocarcinoma progression through interactions with Smad4 and PP1A 7. MYO18A genetic variants were also identified in Ménière's disease pathogenesis 8.