GORASP1 encodes GRASP65, a key structural protein essential for Golgi apparatus organization and function 1. The protein plays a critical role in maintaining Golgi ribbon formation and structure, working in concert with GORASP2/GRASP55 2. GORASP1 facilitates the docking of transport vesicles with Golgi membranes through its interaction with GOLGA2/GM130 3. Beyond structural roles, GORASP1 is involved in cell cycle regulation, with loss of function causing delays in mitotic progression characterized by excess prometaphases and metaphases with polar chr3 1. The first pathogenic human variant (c.1170_1171del) was identified in a patient with neurodevelopmental disorders, revealing that complete loss of GRASP65 causes a novel Golgipathy associated with glycosylation defects including hyposialylation 1. GORASP1 has clinical significance as a potential biomarker, showing frequent methylation and downregulation in various cancers including renal cell carcinoma, non-small cell lung cancer, and nasopharyngeal carcinoma 456. The gene's expression is associated with tumor progression and prognosis, making it a candidate for cancer detection and therapeutic targeting.