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GeneE
2 sources retrieved Β· Most recent: April 2026 Β· Index updated 15 days ago
β“˜GeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
GOLGA8M
golgin A8 family member M
Chromosome 15 Β· 15q13.1
NCBI Gene: 653720Ensembl: ENSG00000188626.7HGNC: HGNC:44404UniProt: H3BSY2
5PubMed Papers
11Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
Golgi organizationGolgi cis cisternacis-Golgi networkGolgi cisterna membranehair colorbenign neoplasm of eyeactinic keratosisAlzheimer disease
✦AI Summary

Based on limited published evidence, GOLGA8M is a golgin family member localized to the cis-Golgi network and Golgi cisterna membrane, involved in Golgi organization. While its specific molecular function remains undefined, GOLGA8M has been identified as a candidate gene associated with HBV-related hepatocellular carcinoma risk through knowledge-based genetic analysis 1, and was incorporated into a cancer-associated fibroblast infiltration biomarker that predicts prognosis in intrahepatic cholangiocarcinoma 2. Further functional characterization is needed to elucidate its role in disease pathogenesis.

Sources cited
1
GOLGA8M was detected as a gene significantly associated with HBV-related hepatocellular carcinoma risk through gene-based association analysis
PMID: 32393195
2
GOLGA8M was incorporated as one of six genes in a cancer-associated fibroblasts infiltration biomarker predictive of prognosis in intrahepatic cholangiocarcinoma
PMID: 38702814
⚠Limited data available β€” This gene has 2 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜11
hair colorOpen Targets
0.32Weak
benign neoplasm of eyeOpen Targets
0.21Weak
actinic keratosisOpen Targets
0.16Weak
Alzheimer diseaseOpen Targets
0.07Suggestive
hepatocellular carcinomaOpen Targets
0.01Suggestive
cholangiocarcinomaOpen Targets
0.00Suggestive
neoplasmOpen Targets
0.00Suggestive
myelodysplastic syndromeOpen Targets
0.00Suggestive
autoimmune diseaseOpen Targets
0.00Suggestive
cancerOpen Targets
0.00Suggestive
viral diseaseOpen Targets
0.00Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
GOLGB1Shared pathway100%GOLGA8AShared pathway100%GOLGA6BShared pathway100%ZFP69BShared pathway100%TJAP1Shared pathway100%ZNF501Shared pathway100%
Tissue Expression6 tissues
Ovary
100%
Liver
73%
Bone Marrow
54%
Heart
15%
Brain
15%
Lung
14%
Gene Interaction Network
Click a node to explore
GOLGA8MGOLGB1GOLGA8AGOLGA6BZFP69BTJAP1ZNF501
PROTEIN STRUCTURE
Preparing viewer…
AlphaFoldAI-predicted Β· UniProt H3BSY2
View on AlphaFold β†—
Constraintβ“˜
LOEUFβ“˜
1.00LoF Tolerant
pLIβ“˜
0.00Tolerant
Observed/Expected LoF0.74 [0.56–1.00]
RankingsWhere GOLGA8M stands among ~20K protein-coding genes
  • #18,336of 20,598
    Most Researched5
  • #9,649of 17,882
    Most Constrained (LOEUF)1.00
Genes detectedGOLGA8M
Sources retrieved2 papers
Response timeβ€”
πŸ“„ Sources
2
1
Integrative analyses of bulk and single-cell transcriptomics reveals the infiltration and crosstalk of cancer-associated fibroblasts as a novel predictor for prognosis and microenvironment remodeling in intrahepatic cholangiocarcinoma.
PMID: 38702814
J Transl Med Β· 2024
1.00
2
Knowledge-based analyses reveal new candidate genes associated with risk of hepatitis B virus related hepatocellular carcinoma.
PMID: 32393195
BMC Cancer Β· 2020
0.50