ZNF501 is a zinc finger transcription factor with dual roles in gene regulation and cellular organization. As a sequence-specific DNA-binding protein, ZNF501 regulates transcription by RNA polymerase II and is essential for maintaining Golgi structural integrity 1. In glioblastoma, ZNF501 sustains cell growth and stemness by transcriptionally activating Frizzled-6 (FZD6), which mediates non-canonical Wnt/JNK signaling; ZNF501 ablation inhibits proliferation, sphere formation, and reduces sensitivity to Temozolomide, while also suppressing tumor formation in vivo 2. Beyond cancer, ZNF501 demonstrates clinical relevance in psychiatric and neurodevelopmental disorders. Transcriptome-wide association studies identified ZNF501 as a depression risk gene with dysregulated expression in the dorsolateral prefrontal cortex 3, and integrative genomic analysis linked ZNF501 expression changes to suicide risk 4. Additionally, ZNF501 shows differential expression in autism spectrum condition blood samples 5. ZNF501 also participates in immune responses, with evidence suggesting involvement in Golgi-mediated immune function 6. These findings establish ZNF501 as a multifunctional regulator with implications for cancer biology, psychiatric disease susceptibility, and immune homeostasis.