GORASP2 (golgi reassembly stacking protein 2) is a multifunctional Golgi structural protein with critical roles in membrane organization and cellular stress responses. As a key component of the Golgi apparatus, GORASP2 functions in concert with GORASP1 to maintain Golgi ribbon formation and organization 1. Beyond classical Golgi architecture, GORASP2 plays essential roles in autophagy regulation. During nutrient starvation, GORASP2 localizes to autophagosome surfaces and promotes phagophore closure by regulating ESCRT-III component association, while controlling RAB7A activity to activate SNARE complexes required for autophagosome-lysosome fusion 2. GORASP2 also facilitates autophagosome maturation by physically linking autophagosomes to lysosomes through LC3 and LAMP2 interactions, and promotes assembly of the PtdIns3K UVRAG complex 3. Clinically, GORASP2 dysfunction associates with multiple pathologies. It mediates unconventional HMGB1 secretion in psoriatic keratinocytes, promoting cutaneous inflammation 4, and similarly facilitates IL6 secretion in head and neck cancer-associated fibroblasts 5. GORASP2 expression increases during myometrial labor and modulates contractility through ATP production regulation 6. Post-mitotic Golgi reassembly requires SIRT2-mediated GORASP2 deacetylation 7. In spinocerebellar ataxia type 3, restoring GORASP2 expression through genome editing improves Golgi structure integrity 8, suggesting therapeutic potential in neurodegenerative diseases.