CDC42BPG (CDC42 binding protein kinase gamma, also known as MRCKgamma) is a serine/threonine kinase that functions as a downstream effector of CDC42 in cytoskeletal reorganization and cell motility. The protein contains magnesium and ATP binding domains and localizes to the cell cytoskeleton and leading edge, where it regulates actomyosin contractility through phosphorylation of MYPT1 and MLC2 1. CDC42BPG expression is restricted to heart and skeletal muscle tissues and is regulated by promoter DNA methylation and Sp1 binding 1. Recent evidence reveals an unexpected role as a negative regulator of selective autophagy, specifically inhibiting pexophagy (peroxisome autophagy) 2. Clinically, CDC42BPG variants have been identified as a novel susceptibility locus for hyperuricemia in genome-wide association studies of Asian populations 34, with genetic variants in CDC42BPG associated with elevated serum uric acid levels and kidney disease-related traits 4. Additionally, CDC42BPG was identified as a differentially expressed gene in phenylalanine-treated neuronal models, implicating it in neurite impairment and synaptic dysfunction relevant to phenylketonuria pathophysiology 5. CDC42BPG variants of uncertain significance have also been detected during whole-exome sequencing diagnostic studies in pediatric patients with suspected genetic diseases 6.