CDH20 (cadherin 20) is a calcium-dependent cell adhesion protein located on chromosome 18-q23 1. As a classical cadherin, it mediates homophilic cell-cell adhesion through β-catenin interactions, contributing to cellular compartmentalization and neural development 2. During embryogenesis, CDH20 is expressed in the developing forebrain, visual system, cerebellum, and neural crest cells destined to become melanoblasts 2. Clinically, CDH20 functions as a tumor suppressor. In cervical cancer, CDH20 is downregulated and its expression negatively correlates with disease progression 3. Mechanistically, CDH20 suppresses epithelial-to-mesenchymal transition (EMT) by interacting with β-catenin to inhibit the TGF-β/Smad/Snail signaling pathway, thereby reducing cancer cell migration and invasion 3. CDH20 mutations occur early in colorectal tumorigenesis, suggesting alterations in cell adhesion pathways are fundamental to adenoma formation 4. Additionally, CDH20 serves as a prognostic marker in glioma, with differential methylation patterns predicting patient outcomes 5. Genome-wide association studies implicate CDH20 variants in obsessive-compulsive disorder susceptibility 6, and DNA methylation at CDH20 mediates birthweight differences in assisted reproductive technology-conceived infants 7.