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GeneE
3 sources retrieved Β· Most recent: April 2026 Β· Index updated 14 days ago
β“˜GeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
CEACAM18
CEA cell adhesion molecule 18
Chromosome 19 Β· 19q13.41
NCBI Gene: 729767Ensembl: ENSG00000213822.7HGNC: HGNC:31949UniProt: A8MTB9
2PubMed Papers
9Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
homophilic cell-cell adhesionheterophilic cell-cell adhesionplasma membraneBarrett's esophagusCrohn's diseasesessile serrated polypColon Sessile Serrated Adenoma/Polyp
✦AI Summary

CEACAM18 is a cell adhesion molecule belonging to the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family, which comprises at least 12 members with diverse tissue expression patterns 1. The protein mediates both heterophilic and homophilic cell-cell adhesion through plasma membrane interactions. CEACAM18 represents an evolutionarily conserved gene with orthologs identified across mammalian species (mouse, rat, and human) located at syntenic chr19 positions 2. Notably, CEACAM18 functions as a framework gene within the mammalian CD33-related Siglec locus, having seeded the evolution of the CD33rSiglec gene cluster through ancient large-scale inverse duplication events occurring over 180 million years ago 3. The CEACAM family exhibits tissue-specific expression patterns suggesting diversified biological functions in controlling tissue homeostasis, immune responses, and host-pathogen interactions 2. While CEACAM5 (CEA) has established clinical utility as a tumor biomarker since 1965, the broader CEACAM family, including CEACAM18, has emerging relevance in tumor immunotherapy applications 1. However, specific functional roles and clinical significance of CEACAM18 individually remain insufficiently characterized in the provided literature.

Sources cited
1
CEACAM family contains 12 members with diverse tissue expression; CEA used as tumor biomarker; CEACAMs involved in tumor immunotherapy
PMID: 32488569
2
CEACAM18 is an evolutionarily conserved gene with orthologs in mouse, rat, and human; CEA family involved in tissue homeostasis, immune responses, and host-pathogen interactions
PMID: 16139472
3
CEACAM18 functions as framework gene in CD33rSiglec locus; seeded mammalian CD33rSiglec cluster through ancient inverse duplication >180 million years ago
PMID: 19337729
⚠Limited data available β€” This gene has 3 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜9
Barrett's esophagusOpen Targets
0.06Suggestive
Crohn's diseaseOpen Targets
0.04Suggestive
sessile serrated polypOpen Targets
0.01Suggestive
Colon Sessile Serrated Adenoma/PolypOpen Targets
0.01Suggestive
Parkinson diseaseOpen Targets
0.01Suggestive
gastric cancerOpen Targets
0.00Suggestive
colorectal carcinomaOpen Targets
0.00Suggestive
neoplasmOpen Targets
0.00Suggestive
esophageal cancerOpen Targets
0.00Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
CADM3Shared pathway100%CEACAM19Protein interaction89%PSG5Shared pathway67%PSG11Shared pathway67%CEACAM8Shared pathway67%IGSF23Shared pathway67%
Tissue Expression6 tissues
Heart
0%
Brain
0%
Bone Marrow
0%
Ovary
0%
Liver
0%
Lung
0%
Gene Interaction Network
Click a node to explore
CEACAM18CADM3CEACAM19PSG5PSG11CEACAM8IGSF23
PROTEIN STRUCTURE
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AlphaFoldAI-predicted Β· UniProt A8MTB9
View on AlphaFold β†—
RankingsWhere CEACAM18 stands among ~20K protein-coding genes
  • #19,094of 20,598
    Most Researched2
Genes detectedCEACAM18
Sources retrieved3 papers
Response timeβ€”
πŸ“„ Sources
3
1
The old CEACAMs find their new role in tumor immunotherapy.
PMID: 32488569
Invest New Drugs Β· 2020
1.00
2
Identification of a novel group of evolutionarily conserved members within the rapidly diverging murine Cea family.
PMID: 16139472
Genomics Β· 2005
0.67
3
Comparative genomics indicates the mammalian CD33rSiglec locus evolved by an ancient large-scale inverse duplication and suggests all Siglecs share a common ancestral region.
PMID: 19337729
Immunogenetics Β· 2009
0.33