CENPF (centromere protein F) is a critical cell cycle regulatory protein that functions primarily in chromosome 1 during mitosis and has emerged as an important oncogenic factor in multiple cancer types. The protein is required for proper kinetochore function and chromosome 1 during cell division 1. In cancer contexts, CENPF is consistently overexpressed and promotes tumor progression and metastasis. In gastric cancer, CENPF facilitates metastasis through N6-methyladenosine (m6A) modification that enhances mRNA stability, leading to activation of MAPK signaling pathways and regulation of FAK nuclear export 2. Similarly, in colorectal cancer, CENPF expression is elevated in metastatic cases and regulated post-translationally through USP4-mediated deubiquitination, with higher expression correlating with poorer disease-free survival 3. CENPF also serves as a diagnostic biomarker in lung adenocarcinoma and triple-negative breast cancer, where its overexpression is associated with poor prognosis 4 5 6. Beyond cancer, CENPF mutations cause Strømme syndrome, a rare genetic disorder characterized by intestinal atresia, ocular abnormalities, and neurological defects 7. The protein's dual roles in normal cell division and cancer progression make it both a potential therapeutic target and prognostic marker across multiple malignancies.