CEP126 (centrosomal protein 126) is a centrosomal regulator essential for multiple cellular processes. Functionally, CEP126 localizes to the centrosome, pericentriolar satellites, and the ciliary base 1. The protein acts as a regulator of microtubule organization by modulating pericentriolar satellite transport, which in turn organizes cell structure 1. CEP126 is necessary for proper microtubule and mitotic spindle organization, and participates in cytokinesis. CEP126 depletion disrupts radial microtubule organization and impairs primary cilium formation in multiple cell lines 1. Diseases of interest include cancers, where CEP126 expression shows prognostic relevance. In head and neck squamous cell carcinoma (HNSCC), CEP126 was identified as a key gene in protein-protein interaction networks associated with cancer progression, appearing as a downregulated gene in higher-grade tumors 2. In breast cancer, CEP126 expression was progressively downregulated from grade I to III tumors, suggesting association with tumor progression and clinical outcomes 3. Additionally, a novel MAML2::CEP126 fusion was identified in an unusual high-grade mucoepidermoid carcinoma case, expanding the spectrum of MAML2 rearrangements in salivary gland tumors 4. Clinically, CEP126 may serve as a prognostic biomarker for cancer grading and patient outcomes, though direct therapeutic applications remain to be established.