CEP44 is a centriole-enriched microtubule-binding protein essential for centrosome assembly and function. Structurally, CEP44 localizes to the proximal end of centrioles and binds A-microtubules within the centriole lumen 1. Its primary function involves centriole biogenesis: CEP44 collaborates with CEP295 and POC1B to ensure proper centriole wall formation, a critical step for centriole-to-centrosome conversion 1. Additionally, CEP44 functions as a centrosome linker component by associating with and stabilizing rootletin, thereby maintaining cohesion between duplicated centrosomes until mitosis 2. During centriole duplication, CEP44 localizes in ninefold symmetry at the centrosome, contributing to the molecular organization that enables procentriole positioning 3. In specialized reproductive cells, CEP44 specifically marks the proximal centriole in spermatozoa 4. Disease relevance includes potential implications in cancer: CEP44 was identified as a differentially expressed gene in triple-negative breast cancer patients responding to neoadjuvant chemotherapy 5, and a novel CEP44-ALK fusion was recently reported in a neuroendocrine tumor patient responsive to ALK-tyrosine kinase inhibitor therapy 6. These findings establish CEP44 as a multifunctional centrosomal protein critical for centriole assembly and centrosome homeostasis.