CEP68 encodes a centrosomal protein critical for maintaining centrosome cohesion during interphase. CEP68 localizes to fibres emanating from the proximal ends of centrioles and functions as part of a proteinaceous linker structure that prevents premature centrosome splitting 1. The protein cooperates with rootletin and C-Nap1 in centrosome cohesion, with these proteins being interdependent for proper centriole association 1. CEP68 also serves as a molecular link between C-Nap1 and Cep68 through interaction with centlein, forming a C-Nap1-centlein-Cep68 complex essential for centrosome cohesion 2. The protein is required for proper localization of CDK5RAP2/Cep215 to the centrosome and forms complexes with Cep215 and PCNT 3. CEP68 is tightly regulated during the cell cycle through phosphorylation by PLK1 and Nek2, leading to its degradation by the SCF(βTrCP) ubiquitin ligase complex at mitosis to allow centrosome separation 34. Rootletin protects CEP68 from VHL-mediated proteasomal degradation, and disruption of this protection results in centrosome splitting 5. Genetic variants in CEP68 have been associated with aspirin-intolerant asthma and NSAID hypersensitivity reactions 67.