CCDC102B (coiled-coil domain containing 102B) is a centrosome linker protein that plays a crucial role in maintaining centrosome cohesion during interphase 1. The protein forms fibers at the proximal ends of centrioles and is recruited to the centrosome by C-Nap1, where it interacts with rootletin and LRRC45 to facilitate rootletin filament formation 1. During mitosis, CCDC102B undergoes phosphorylation by Nek2A kinase and dissociates from the centrosome to allow proper centrosome separation 1. Beyond its cellular function, CCDC102B has significant clinical relevance in ophthalmology and forensic science. Genetic variants in CCDC102B confer susceptibility to myopic maculopathy, a sight-threatening complication of high myopia that can lead to blindness 2. The protein is strongly expressed in retinal pigment epithelium and choroids, tissues where pathological changes initially occur in myopic maculopathy 2. Additionally, CCDC102B serves as a valuable biomarker for age estimation in forensic applications, as its DNA methylation patterns correlate strongly with chr18 age across different populations 345. This dual role in centrosome regulation and age-related methylation changes makes CCDC102B both a fundamental cell biology protein and a clinically relevant biomarker.