CROCC (ciliary rootlet coiled-coil, rootletin) encodes a major structural protein essential for ciliary function and centrosome organization. The protein serves as the primary building block of ciliary rootlets, cytoskeletal-like structures that extend from the basal body toward the cell nucleus and are required for proper cilium positioning and assembly 1. CROCC functions as a centrosome linker component, maintaining centrosome cohesion before mitosis and enabling proper chromosome 1 2. The protein directly interacts with PCM1 to facilitate docking of centriolar satellites near centrosomes, which is critical for cilia formation 3. Disease relevance includes colorectal cancers, where CROCC mutations cause centrosome segregation errors and tetraploid formation, contributing to aggressive rhabdoid phenotypes 24. CROCC is also implicated in gallbladder cancer progression through epithelial-mesenchymal transition regulation 5 and has been identified as a predictive biomarker in Alzheimer's disease 6. Additionally, variants in CROCC contribute to familial tall stature phenotypes 7, and the human-specific duplicate CROCCP2 modulates cortical development by regulating ciliary dynamics and mTOR signaling 8. These findings establish CROCC as a crucial regulator of cellular organization with broad implications for development and disease.