PCNT encodes pericentrin, a structural protein of the pericentriolar material (PCM) essential for centrosome organization and microtubule nucleation 1. During mitosis, PCNT maintains centriole association within spindle poles and undergoes specific cleavage to facilitate centriole separation and conversion during mitotic exit 2. PCNT also interacts with DISC1 in regulating microtubule network formation and may inhibit premature centrosome splitting via NEK2 kinase inhibition 3. Biallelic loss-of-function PCNT mutations cause microcephalic osteodysplastic primordial dwarfism type II (MOPDII), characterized by extreme growth retardation, microcephaly, skeletal dysplasia, and impaired cell cycle progression 4. Approximately 50% of MOPDII patients develop neurovascular abnormalities including intracranial aneurysms and subarachnoid hemorrhages 35. Heterozygous PCNT variants in exon 38 (protein-protein interaction domain) are associated with increased cerebrovascular disease risk in families with intracranial aneurysms or subarachnoid hemorrhage 3. Beyond centrosome function, PCNT participates in LC3-dynein adaptor complexes independent of autophagy, facilitating influenza A virus uncoating during cytoplasmic entry 6. PCNT was identified in networks linking hyperglycemia, diabetic complications, and SARS-CoV-2 pathogenesis 7.