TUBG1 encodes tubulin gamma 1, a key component of the gamma-tubulin ring complex (γTuRC) that mediates microtubule nucleation from centrosomes 1. The protein regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protofilaments, which is critical for centrosome duplication and spindle formation during cell division 1. TUBG1 forms a cellular meshwork that enables centrosome movement by providing an interacting platform for positional changes 2. Mutations in TUBG1 cause tubulinopathies, specifically cortical dysplasia with brain malformations, characterized by microcephaly, abnormal corticogenesis, and impaired neuronal migration 13. In cancer, TUBG1 is frequently upregulated and promotes oncogenesis through multiple mechanisms. In hepatocellular carcinoma, overexpression correlates with poor prognosis and promotes cell proliferation, invasion, and migration 45. Mechanistically, TUBG1 appears to regulate cell cycle progression through ATR/P53-apoptosis pathways and affects expression of cyclins and CDK proteins 6. The protein also influences immune cell infiltration patterns in tumor environments 4. TUBG1's dual role in normal neurodevelopment and cancer progression makes it both a critical developmental regulator and potential therapeutic target.