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GeneE
0 sources retrieved Β· Most recent: April 2026 Β· Index updated 15 days ago
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TUBB8B
tubulin beta 8B
Chromosome 18 Β· 18p11.32
NCBI Gene: 260334Ensembl: ENSG00000173213.11HGNC: HGNC:24983UniProt: A6NNZ2
12PubMed Papers
13Diseases
1Drugs
0Pathogenic Variants
CLINICAL
Clinical Trials
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
extracellular exosomeGTP bindingmicrotubule cytoskeleton organizationmicrotubuleviral diseaserenal cell carcinomacolorectal cancerbreast cancer
✦AI Summary

AI summary not yet available. Showing NCBI Gene summary.

tubulin beta 8B

⚠Limited data available β€” This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜13
viral diseaseOpen Targets
0.46Moderate
breast cancerOpen Targets
0.07Suggestive
colorectal cancerOpen Targets
0.07Suggestive
neuroblastomaOpen Targets
0.07Suggestive
non-small cell lung carcinomaOpen Targets
0.07Suggestive
renal cell carcinomaOpen Targets
0.07Suggestive
lymphoid neoplasmOpen Targets
0.04Suggestive
prostate cancerOpen Targets
0.03Suggestive
diabetes mellitusOpen Targets
0.02Suggestive
cancerOpen Targets
0.01Suggestive
neoplasmOpen Targets
0.00Suggestive
small cell lung carcinomaOpen Targets
0.00Suggestive
chronic kidney diseaseOpen Targets
0.00Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Drug Targets1
ABT-751Phase II
Tubulin beta inhibitor
Related Genes
TUBB6Shared pathway100%TUBA1AProtein interaction95%TUBA3EProtein interaction85%TUBA3CProtein interaction85%TUBA4BProtein interaction76%TUBAL3Protein interaction75%
Tissue Expression6 tissues
Ovary
100%
Brain
36%
Lung
29%
Liver
21%
Bone Marrow
14%
Heart
0%
Gene Interaction Network
Click a node to explore
TUBB8BTUBB6TUBA1ATUBA3ETUBA3CTUBA4BTUBAL3
PROTEIN STRUCTURE
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AlphaFoldAI-predicted Β· UniProt A6NNZ2
View on AlphaFold β†—
Constraintβ“˜
LOEUFβ“˜
1.45LoF Tolerant
pLIβ“˜
0.00Tolerant
Observed/Expected LoF0.97 [0.66–1.45]
RankingsWhere TUBB8B stands among ~20K protein-coding genes
  • #16,615of 20,598
    Most Researched12
  • #14,887of 17,882
    Most Constrained (LOEUF)1.45
Genes detectedTUBB8B
Sources retrieved0 papers
Response timeβ€”