TUBGCP6 (tubulin gamma complex component 6) is a critical component of the gamma-tubulin ring complex (γ-TuRC) that mediates microtubule nucleation at centrosomes 1. The protein functions by regulating minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protofilaments, playing an essential role in centrosome duplication and spindle formation during cell division 12. TUBGCP6 expression requires proper pre-mRNA splicing by factors like WBP11 and SF3B14, and loss of these splicing factors leads to TUBGCP6 depletion and subsequent centriole duplication defects 12. Biallelic loss-of-function variants in TUBGCP6 cause autosomal recessive microcephaly and chorioretinopathy-1 (MCCRP1), a rare disorder characterized by microcephaly, cognitive impairment, and variable ophthalmological anomalies including chorioretinopathy 3. The clinical presentation can be recognized prenatally with visual impairment becoming evident during the first year of life 3. Additionally, TUBGCP6 mutations have been associated with lissencephaly spectrum disorders and identified as prognostic markers in pancreatic cancer 45. The gene's role in centrosome function makes it crucial for proper brain development and cellular division.