TUBGCP2 encodes gamma-tubulin complex protein 2 (GCP2), a core component of the gamma-tubulin ring complex (γ-TuRC) that mediates microtubule nucleation at centrosomes 1. The protein regulates minus-end nucleation of alpha-beta tubulin heterodimers, which is critical for centrosome duplication and spindle formation during cell division 1. TUBGCP2 plays an essential role in neuronal migration and brain development, with the γ-TuRC complex controlling microtubule assembly necessary for proper cortical development 12. Bi-allelic pathogenic variants in TUBGCP2 cause autosomal recessive neurodevelopmental disorders characterized by microcephaly, lissencephaly spectrum malformations including pachygyria and subcortical band heterotopia, and developmental delay 13. These cortical malformations result from disrupted neuronal migration due to defective microtubule nucleation 1. Functional studies demonstrate that TUBGCP2 mutations affect electrostatic interactions within the γ-TuRC complex and dysregulate proteins involved in cytoskeletal assembly and neuronal homeostasis 2. The protein has also emerged as a potential therapeutic target, with compounds like CM14 showing anti-cancer activity through direct TUBGCP2 interaction in various malignancies 4.