TUBGCP3 (tubulin gamma complex component 3) is a structural component of the gamma-tubulin ring complex (γ-TuRC), which serves as the primary microtubule nucleation center in eukaryotic cells 1. As part of the γ-TuRC, TUBGCP3 mediates the nucleation of microtubule filaments from centrosomes, a process critical for proper spindle formation during cell division 1. The protein exhibits dynamic localization to centrosomes throughout the cell cycle, with peak expression during G2 and early mitosis phases 1. TUBGCP3 directly interacts with key microtubule structural components including α-tubulin, β-tubulin, γ-tubulin, and other γ-tubulin complex proteins 1. Cross-species functional studies demonstrate that TUBGCP3 function is highly conserved, with human GCP3 capable of functionally replacing its fission yeast ortholog Alp6 and assembling normally into the γ-TuRC complex 2. Clinically, TUBGCP3 shows disease relevance in multiple contexts: it is differentially expressed during human oocyte maturation from germinal vesicle to metaphase I stages 3, overexpressed in tetraploid mantle cell lymphomas where centrosome aberrations contribute to chr13 instability 4, and identified as a potential therapeutic target in basal-like breast cancers 5. Additionally, circular RNA derived from TUBGCP3 can encode a novel protein that promotes gastric cancer progression by inhibiting ferroptosis 6.