CDC14C is a dual-specificity phosphatase belonging to the highly conserved CDC14 family of cell-cycle regulators 1. While the budding yeast homolog Cdc14 plays central roles in mitotic exit and cytokinesis by counteracting cyclin-dependent kinase activity, the functional conservation of mammalian CDC14 paralogs remains unclear 1. Notably, CDC14C expression appears absent or negligible in commonly studied human cell lines (RPE1 cells), suggesting cell-type or tissue-specific expression patterns 2. Unlike yeast, human CDC14A and CDC14B are individually dispensable for mitotic progression and cytokinesis; instead, emerging evidence indicates these paralogs have non-canonical roles in ciliogenesis regulation 2. This functional divergence between yeast and human CDC14 phosphatases indicates that mammalian orthologs have evolved specialized functions distinct from ancestral cell-cycle control mechanisms. Regarding disease relevance, a CDC14C pseudogene was identified among eight pseudogenes more abundant in plasma-derived exosomes from lung adenocarcinoma patients compared to healthy volunteers, suggesting potential diagnostic biomarker utility, though the functional significance remains unclear 3. Overall, CDC14C appears to represent a functionally specialized paralog with limited characterized roles in standard cell-cycle contexts.