CIBAR2 (CBY1-interacting BAR domain containing protein 2) is a membrane-remodeling protein that functions primarily in ciliogenesis. The protein contains a BAR (Bin/Amphiphysin/Rvs) domain and operates in cooperation with Chibby1 (CBY1) to facilitate early-stage ciliogenesis by recruiting and fusing endosomal vesicles at distal appendages of centrioles/basal bodies 1. CIBAR2 colocalizes with CBY1 at centriolar regions in multiciliated cells, with its centriolar localization largely dependent on CBY1 interaction 1. The BAR domain mediates membrane-remodeling activities that promote vesicle organization and transport of Rab8-containing compartments during cilia assembly 1. Beyond ciliogenesis, recent machine learning analysis identified CIBAR2 (FAM92B) as a potential Alzheimer's disease risk gene, though its mechanistic role in neurodegeneration remains unclear 2. A genetic association study found no significant link between FAM92B variants and Crohn's disease susceptibility in pediatric patients 3. The protein's primary established function centers on ciliary biogenesis, while its broader disease relevance warrants further investigation.