SASS6 (SAS-6 centriolar assembly protein) is a central scaffolding component essential for centriole assembly and centrosome biogenesis 1. It ensures the 9-fold symmetry of centrioles and is required for both mother-centriole-dependent duplication and deuterosome-dependent centriole amplification in multiciliated cells, with a specific role in recruiting STIL for centriole amplification 2. SASS6 maintains centriole architecture and regulates proper centrosome formation 3. Pathogenic biallelic SASS6 variants cause autosomal recessive primary microcephaly 14 (MCPH14), characterized by significantly reduced brain size 4. Recent evidence reveals an expanded phenotype including fetal growth restriction associated with SASS6 deficiency 4. Beyond its developmental role, SASS6 demonstrates oncogenic functions in multiple cancers. It is frequently upregulated in lung adenocarcinoma and esophageal squamous cell carcinoma, correlating with poor prognosis 53. SASS6 promotes tumor cell proliferation by inhibiting p53 signaling and activating the YAP/TAZ pathway 36. SASS6 overexpression facilitates centrosome amplification through the PLK4/SASS6 axis, driving polyploid giant cancer cell formation and therapeutic resistance 7. High SASS6 expression predicts immune-desert tumor subtypes with poor immunotherapy response 8.