CEP152 (centrosomal protein 152) is a critical scaffolding protein essential for centrosome duplication and centriole biogenesis. As a primary function, CEP152 acts as a molecular scaffold that facilitates the recruitment and activation of PLK4 (Polo-like kinase 4), a key regulator of centriole duplication 1. CEP152 cooperates with CEP192 to recruit PLK4 to centrioles, with both proteins being necessary for PLK4 localization and centriole duplication 2. Mechanistically, CEP152 binding to PLK4 increases phosphorylation and kinase activation, controlling both the localization and levels of phosphorylated PLK4 at the proximal end of centrioles 1. CEP152 develops complex organizational patterns during centriole maturation, creating flexibility for PLK4 and procentriole placement 3. The protein forms complexes with CEP57 and CEP63, which are regulated by APC/C-mediated ubiquitylation during mitosis to control spindle assembly 4. Disease relevance includes associations with primary microcephaly and Seckel syndrome, reflecting its critical role in proper cell division. Clinically, mutations in CEP152 disrupt centrosome function, leading to neurodevelopmental disorders characterized by reduced brain size due to impaired neuronal proliferation during development.