CEP70 (centrosomal protein 70) is a crucial regulator of microtubule organization and cellular processes essential for proper cell division and migration. The protein localizes to centrosomes and plays a fundamental role in organizing both preexisting and nascent microtubules during interphase, while being required for mitotic spindle organization and orientation during cell division 1. CEP70 enhances microtubule stability by interacting with histone deacetylase 6 (HDAC6) and regulating tubulin acetylation, making microtubules more resistant to depolymerizing agents 1. The protein is critical for angiogenesis, promoting endothelial cell migration, polarization, and tube formation through microtubule rearrangement and activation of Cdc42 and Rac1 2. In reproductive biology, CEP70 is essential for spermiogenesis, specifically for acrosome biogenesis and flagella formation, with knockout mice showing male sterility due to abnormal sperm development 3. Clinically, CEP70 overexpression is associated with multiple cancers, including breast and pancreatic cancers, where it promotes tumor growth, metastasis, and correlates with poor prognosis 45. Additionally, CEP70 mediates paclitaxel sensitivity in breast cancer by interacting with tubulin and enhancing drug-induced microtubule assembly 6.