CEP85 is a centrosomal protein with dual regulatory roles in centriole biology and cell migration. Structurally, CEP85 directly interacts with STIL through a conserved binding interface 1, which is essential for efficient centriolar targeting of STIL and PLK4 activation during early centriole duplication 1. The CEP85-STIL complex additionally modulates PLK4-driven cytoskeletal rearrangements and directional cell migration by promoting ARP2 phosphorylation and actin cytoskeleton reorganization at the cell leading edge 2. CEP85 also functions as a negative regulator of NEK2A kinase, suppressing centrosome disjunction and maintaining centrosome integrity during interphase through antagonism of premature centrosome separation 3. Disease relevance includes cancer, where CEP85 upregulation promotes glioblastoma proliferation and migration through a circRNA-SMO/miR-326 regulatory axis 4, and male infertility, as CEP85 knockout studies indicate its importance in spermatogenesis 5. CEP85's multiple regulatory functions at centrosomes position it as a critical node coordinating centriole assembly, centrosome integrity, and cancer-associated cell migration.