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GeneE
0 sources retrieved Β· Most recent: April 2026 Β· Index updated 14 days ago
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CHAC1
ChaC glutathione specific gamma-glutamylcyclotransferase 1
Chromosome 15 Β· 15q15.1
NCBI Gene: 79094Ensembl: ENSG00000128965.13HGNC: HGNC:28680UniProt: Q9BUX1
30PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
glutathione specific gamma-glutamylcyclotransferase activitynegative regulation of Notch signaling pathwayintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stresscytosolprostate cancerFamilial prostate cancerobesityneoplasm
✦AI Summary

AI summary not yet available. Showing NCBI Gene summary.

ChaC glutathione specific gamma-glutamylcyclotransferase 1

⚠Limited data available β€” This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜20
prostate cancerOpen Targets
0.12Weak
Familial prostate cancerOpen Targets
0.11Weak
obesityOpen Targets
0.11Weak
neoplasmOpen Targets
0.10Weak
hepatocellular carcinomaOpen Targets
0.08Suggestive
cancerOpen Targets
0.08Suggestive
lung adenocarcinomaOpen Targets
0.08Suggestive
Helicobacter pylori infectious diseaseOpen Targets
0.08Suggestive
gastric cancerOpen Targets
0.07Suggestive
cystic fibrosisOpen Targets
0.07Suggestive
ovarian cancerOpen Targets
0.07Suggestive
psoriasisOpen Targets
0.06Suggestive
essential hypertensionOpen Targets
0.06Suggestive
breast cancerOpen Targets
0.05Suggestive
cholangiocarcinomaOpen Targets
0.05Suggestive
hypertensionOpen Targets
0.05Suggestive
chronic kidney diseaseOpen Targets
0.04Suggestive
coronary artery diseaseOpen Targets
0.04Suggestive
coronary atherosclerosisOpen Targets
0.04Suggestive
ulnar-mammary syndromeOpen Targets
0.04Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
GPX8Protein interaction100%GPX6Protein interaction100%GSTO2Protein interaction96%GGT6Protein interaction92%GGT1Protein interaction91%GPX2Protein interaction91%
Tissue Expression6 tissues
Brain
100%
Liver
84%
Lung
54%
Heart
24%
Bone Marrow
22%
Ovary
8%
Gene Interaction Network
Click a node to explore
CHAC1GPX8GPX6GSTO2GGT6GGT1GPX2
PROTEIN STRUCTURE
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AlphaFoldAI-predicted Β· UniProt Q9BUX1
View on AlphaFold β†—
Constraintβ“˜
LOEUFβ“˜
1.43LoF Tolerant
pLIβ“˜
0.00Tolerant
Observed/Expected LoF1.00 [0.71–1.43]
RankingsWhere CHAC1 stands among ~20K protein-coding genes
  • #11,883of 20,598
    Most Researched30
  • #14,683of 17,882
    Most Constrained (LOEUF)1.43
Genes detectedCHAC1
Sources retrieved0 papers
Response timeβ€”