GGT7 is a gamma-glutamyltransferase that hydrolyzes and transfers gamma-glutamyl moieties from glutathione and other gamma-glutamyl compounds to acceptors 1. Beyond its classical role in glutathione metabolism, GGT7 functions as a SREBP2-dependent cholesterol regulator that positively controls cellular cholesterol levels and LDL-C uptake through interaction with the motor protein MYH10; genetic ablation in mice reduces serum cholesterol 2. GGT7 plays a tumor-suppressive role in multiple cancer types. In glioblastoma, low GGT7 expression correlates with poor prognosis, while GGT7 overexpression reduces proliferation by suppressing reactive oxygen species (ROS) levels 3. In gastric cancer, GGT7 is an independent prognostic factor that suppresses tumor growth and metastasis by directly binding RAB7 to induce mitophagy, subsequently inhibiting ROS and MAPK signaling 4. Conversely, in prostate cancer, GGT6 and GGT7 are downregulated in tumors, with GGT7 identified as a potential neuroendocrine prostate cancer biomarker 5. Genetic studies reveal that GGT7 polymorphisms (rs6119534, rs11546155) associate with increased acute pancreatitis risk, particularly under environmental stress 6. GGT7 variants also show causal associations with attention-deficit/hyperactivity disorder through alternative splicing effects 7. Additionally, GGT7 is upregulated in port wine birthmark vasculatures where it contributes to pathological vascular remodeling 8.