CHST11 (carbohydrate sulfotransferase 11) catalyzes the transfer of sulfate to position 4 of N-acetylgalactosamine residues in chondroitin sulfate, a major proteoglycan component of cartilage and extracellular matrices 1. The enzyme functions in the Golgi membrane during chondroitin sulfate biosynthesis and preferentially sulfates glucuronic acid-linked GalNAc units. CHST11 generates P-selectin-reactive chondroitin sulfate structures on cancer cell surfaces that facilitate metastatic cell adhesion and invasion 1. Expression is elevated across multiple cancer types including breast, lung, pancreatic, hepatocellular, and renal cell carcinomas, where it correlates with poor prognosis, increased metastatic potential, and chemoresistance 2345. In hepatocellular carcinoma, CHST11 promotes metastasis and drug resistance through activation of MAPK signaling pathways 6. DNA methylation controls CHST11 expression in breast cancer, with hypomethylation associated with aggressive basal-like subtypes 2. The gene shows promise as both a prognostic biomarker and therapeutic target, with computational studies identifying potential inhibitors like capsaicin 7. CHST11's role in immune cell infiltration and metabolic pathways further emphasizes its clinical significance in cancer progression 45.