CLEC10A is a C-type lectin receptor expressed on immature dendritic cells (DCs), monocyte-derived DCs, alternatively activated macrophages, and oocytes 1. It functions as a pattern recognition receptor with Ca2+-dependent binding specificity for N-acetylgalactosamine (GalNAc)-terminated glycans, including Tn antigens, T antigens, and gangliosides 1. CLEC10A serves as a specific marker for human CD1c+ conventional dendritic cells (cDC2) and exhibits rapid endocytic internalization 2. At the APC-T cell interface, CLEC10A recognizes GalNAc-modified CD45 on effector T cells, downregulating CD45 phosphatase activity and promoting tolerogenic dendritic cell maturation with immune-suppressive effects 1. As an endocytic receptor, CLEC10A internalizes tumor-associated Tn antigens and their sialylated variants for MHC-mediated antigen presentation to CD8+ and CD4+ T cells, contributing to antitumor immunity 1. On skin macrophages, CLEC10A inhibits TLR4-mediated inflammatory responses through its immunoreceptor tyrosine activating motif 3. In pancreatic ductal adenocarcinoma, CLEC10A expression on tumor-associated macrophages correlates with poor prognosis 4. CLEC10A+ dendritic cells interact with tissue-resident memory Th17 cells in spondyloarthritis 5, and respond to oncolytic virotherapy 6. Its pleiotropic functions balance pro-inflammatory antitumor responses with anti-inflammatory tolerogenic effects 7.