CLEC17A (C-type lectin domain containing 17A) is a cell surface receptor belonging to the C-type lectin family that binds glycans with terminal alpha-linked mannose or fucose residues 1. The protein functions as a pattern recognition receptor involved in carbohydrate-mediated cell-cell communication, particularly within germinal centers 2. CLEC17A is expressed on lymph node B cells and demonstrates cell adhesion properties preferentially toward epithelial cells through fucose-binding interactions 3. Mechanistically, CLEC17A recognizes fucosylated antigens on cell surfaces and mediates adhesion through these glycan-ligand interactions 3. The receptor contains conserved mannose or fucose-binding sequence motifs and intracellular signaling domains 1. Clinically, CLEC17A has emerged as a prognostic marker in multiple cancers. In lung adenocarcinoma, CLEC17A expression is associated with tumor microenvironment composition and patient survival outcomes, with lower CLEC17A levels correlating with improved immunotherapy response 45. Similarly, in colorectal cancer, CLEC17A is part of an immunogenic cell death-related gene signature predicting prognosis 6. High expression of CLEC17A in the tumor microenvironment associates with reduced immune cell infiltration and worse prognosis in lung adenocarcinoma 7.