CLEC11A (C-type lectin domain containing 11A) is a secreted glycoprotein that functions as a growth factor with diverse roles in cellular differentiation and proliferation. The protein promotes osteogenesis by stimulating mesenchymal progenitor differentiation into mature osteoblasts and plays important roles in bone construction, remodeling, and fracture repair through activation of Wnt/β-catenin signaling pathways 12. CLEC11A also enhances insulin secretion and promotes proliferation in human pancreatic beta-cells by upregulating transcription factors MAFA and PDX1 3. In hematopoiesis, CLEC11A was initially identified as a growth factor for hematopoietic progenitor cells and regulates hematopoietic differentiation and homeostasis 1. The protein contains integrin-binding motifs (RGD and LDT) and a C-type lectin domain, enabling receptor-ligand interactions that activate downstream signaling cascades 1. Clinically, CLEC11A expression is associated with poor prognosis in gastric cancer and acute myeloid leukemia, where it contributes to tumor progression and immune evasion 456. In colorectal cancer, cancer-associated fibroblasts secrete CLEC11A under hypoxic conditions, promoting lymphatic metastasis through LGR5 receptor binding and Wnt pathway activation 7.