TMEM250 — transmembrane protein 250

5 sources retrieved · Most recent: April 2026 · Index updated 4 months ago

7PubMed Papers

#17,814 · top 92% of 19K genes

11Diseases

top 95%

0Drugs

0Pathogenic Variants

Experimental GO EvidenceSwiss-Prot Reviewed

protein bindingpositive regulation of cell population proliferationpositive regulation of viral processnucleusHypercholesterolemiavertebral column disorderalcohol drinkingnon-neoplastic bile duct disorder

AI Summary

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transmembrane protein 250

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.

Disease Associations11

HypercholesterolemiaOpen Targets

0.20Weak

alcohol drinkingOpen Targets

0.18Weak

non-neoplastic bile duct disorderOpen Targets

0.18Weak

seasonal allergic rhinitisOpen Targets

0.18Weak

vertebral column disorderOpen Targets

0.18Weak

metastatic melanomaOpen Targets

0.01Suggestive

meningeal tuberculosisOpen Targets

0.00Suggestive

non-small cell lung carcinomaOpen Targets

0.00Suggestive

lymphomaOpen Targets

0.00Suggestive

ovarian cancerOpen Targets

0.00Suggestive

ovarian serous cystadenocarcinomaOpen Targets

0.00Suggestive

Pathogenic Variants

No pathogenic variants reported on ClinVar for this gene.

Tissue Expression6 tissues

Liver

100%

Lung

78%

Brain

69%

Ovary

67%

Heart

55%

Bone Marrow

24%

Gene Interaction Network6 neighbors

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StructureAlphaFold

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AlphaFoldAI-predicted · UniProt H0YL14

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ConstraintgnomAD v4.1

LOEUFⓘ

1.72LoF Tolerant

pLIⓘ

0.00Tolerant

Observed/Expected LoF0.97 [0.55–1.72]

Rankings2 dim

Where TMEM250 stands among ~20K protein-coding genes

#17,969of 20,598
Most Researched7
#16,175of 17,882
Most Constrained (LOEUF)1.72