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GeneE
0 sources retrieved Β· Most recent: April 2026 Β· Index updated 14 days ago
β“˜GeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
TMEM250
transmembrane protein 250
Chromosome 9 Β· 9q34.3
NCBI Gene: 90120Ensembl: ENSG00000238227.9HGNC: HGNC:31009UniProt: H0YL14
7PubMed Papers
9Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
protein bindingpositive regulation of cell population proliferationpositive regulation of viral processnucleusHypercholesterolemiaNon-Neoplastic Bile Duct Disordervertebral column disordermetastatic melanoma
✦AI Summary

AI summary not yet available. Showing NCBI Gene summary.

transmembrane protein 250

⚠Limited data available β€” This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜9
HypercholesterolemiaOpen Targets
0.22Weak
Non-Neoplastic Bile Duct DisorderOpen Targets
0.21Weak
vertebral column disorderOpen Targets
0.18Weak
metastatic melanomaOpen Targets
0.01Suggestive
meningeal tuberculosisOpen Targets
0.00Suggestive
non-small cell lung carcinomaOpen Targets
0.00Suggestive
lymphomaOpen Targets
0.00Suggestive
ovarian cancerOpen Targets
0.00Suggestive
ovarian serous cystadenocarcinomaOpen Targets
0.00Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
EGR4Shared pathway100%TSPAN31Shared pathway100%CDCA7LShared pathway100%SEPTIN7Protein interaction71%SEPTIN1Protein interaction71%SEPTIN2Protein interaction71%
Tissue Expression6 tissues
Liver
100%
Lung
78%
Brain
69%
Ovary
67%
Heart
55%
Bone Marrow
24%
Gene Interaction Network
Click a node to explore
TMEM250EGR4TSPAN31CDCA7LSEPTIN7SEPTIN1SEPTIN2
PROTEIN STRUCTURE
Preparing viewer…
AlphaFoldAI-predicted Β· UniProt H0YL14
View on AlphaFold β†—
Constraintβ“˜
LOEUFβ“˜
1.72LoF Tolerant
pLIβ“˜
0.00Tolerant
Observed/Expected LoF0.97 [0.55–1.72]
RankingsWhere TMEM250 stands among ~20K protein-coding genes
  • #17,969of 20,598
    Most Researched7
  • #16,175of 17,882
    Most Constrained (LOEUF)1.72
Genes detectedTMEM250
Sources retrieved0 papers
Response timeβ€”