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GeneE
0 sources retrieved Β· Most recent: April 2026 Β· Index updated 15 days ago
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CLEC1A
C-type lectin domain family 1 member A
Chromosome 12 Β· 12p13.2
NCBI Gene: 51267Ensembl: ENSG00000150048.10HGNC: HGNC:24355UniProt: B3KRP6
20PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
protein bindingtransmembrane signaling receptor activitysignal transductionplasma membranealcohol drinkingbile duct disorderneurodegenerative diseasetype 1 diabetes mellitus
✦AI Summary

AI summary not yet available. Showing NCBI Gene summary.

C-type lectin domain family 1 member A

⚠Limited data available β€” This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜20
alcohol drinkingOpen Targets
0.30Weak
bile duct disorderOpen Targets
0.29Weak
neurodegenerative diseaseOpen Targets
0.25Weak
type 1 diabetes mellitusOpen Targets
0.20Weak
neoplasmOpen Targets
0.07Suggestive
autoimmune diseaseOpen Targets
0.04Suggestive
immune system diseaseOpen Targets
0.04Suggestive
type II hypersensitivity reaction diseaseOpen Targets
0.04Suggestive
Chronic mucocutaneous candidosisOpen Targets
0.04Suggestive
Autosomal recessive systemic lupus erythematosusOpen Targets
0.04Suggestive
autosomal systemic lupus erythematosus type 16Open Targets
0.04Suggestive
immunoglobulin A deficiency 2Open Targets
0.04Suggestive
pemphigus vulgarisOpen Targets
0.04Suggestive
keratitisOpen Targets
0.04Suggestive
Hashimoto's thyroiditisOpen Targets
0.03Suggestive
IgAD1Open Targets
0.03Suggestive
C1 inhibitor deficiencyOpen Targets
0.03Suggestive
autoimmune lymphoproliferative syndromeOpen Targets
0.03Suggestive
autoimmune lymphoproliferative syndrome type 1Open Targets
0.03Suggestive
immunodeficiency 25Open Targets
0.03Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
MS4A18Shared pathway100%MS4A13Shared pathway100%ADGRD2Shared pathway100%MS4A10Shared pathway100%MS4A6EShared pathway100%MS4A15Shared pathway100%
Tissue Expression6 tissues
Lung
100%
Heart
40%
Ovary
33%
Liver
13%
Brain
9%
Bone Marrow
3%
Gene Interaction Network
Click a node to explore
CLEC1AMS4A18MS4A13ADGRD2MS4A10MS4A6EMS4A15
PROTEIN STRUCTURE
Preparing viewer…
AlphaFoldAI-predicted Β· UniProt Q8NC01
View on AlphaFold β†—
Constraintβ“˜
LOEUFβ“˜
1.53LoF Tolerant
pLIβ“˜
0.00Tolerant
Observed/Expected LoF1.12 [0.83–1.53]
RankingsWhere CLEC1A stands among ~20K protein-coding genes
  • #14,131of 20,598
    Most Researched20
  • #15,339of 17,882
    Most Constrained (LOEUF)1.53
Genes detectedCLEC1A
Sources retrieved0 papers
Response timeβ€”