CORO1C (coronin 1C) is an actin-binding protein encoded on chromosome 12.1 that functions as a regulator of cell motility and cytoskeletal dynamics 1. The protein contains conserved WD repeats and coiled-coil motifs characteristic of the coronin family and co-localizes with F-actin 1. CORO1C is ubiquitously expressed across human tissues 1 and plays roles in myogenic differentiation, focal adhesion regulation, and lamellipodium morphogenesis. Mechanistically, CORO1C functions downstream of transcriptional regulators like YB-1, which indirectly controls its expression 2. In spinal muscular atrophy, CORO1C works with the actin-binding protein PLS3 to restore impaired endocytosis in a calcium-dependent manner 3. The protein is also regulated by the lncMALAT1/miR-133a-3p axis, which controls its stability 4. Clinically, CORO1C overexpression associates with aggressive cancer phenotypes across multiple malignancies. Elevated CORO1C predicts poor survival in pancreatic ductal adenocarcinoma and gastric cancer 56. In colorectal cancer, CORO1C interacts with RAD23B to promote invadopodia formation and metastasis 7. CORO1C participates in circular RNA-mediated regulation of laryngeal squamous cell carcinoma progression 8. Conversely, CORO1C downregulation contributes to trophoblast dysfunction in preeclampsia 4, suggesting context-dependent pathological roles.