CORO2A (coronin 2A) is an actin-binding protein containing WD repeat domains that functions as a component of the nuclear receptor co-repressor (NCoR) complex 1. Primary function: CORO2A mediates actin-dependent de-repression of inflammatory response genes through interaction with oligomeric nuclear actin, enabling removal of NCoR complexes from target gene promoters 1. This process is regulated by SUMOylated liver X receptors and calcium/calmodulin-dependent protein kinase IIγ-dependent phosphorylation 1. CORO2A protein stability is maintained through deubiquitination by USP19, which affects retinoic acid receptor transcriptional repression 2. Disease relevance: CORO2A expression is significantly upregulated in multiple cancers including pancreatic ductal adenocarcinoma and oral squamous cell carcinoma, correlating with poor prognosis 34. High CORO2A expression predicts reduced 5-year survival in both PDAC and OSCC patients 34. CORO2A knockdown suppresses cancer cell migration and invasion 34. Clinical significance: The SNP CORO2A rs1985859 is associated with radiosensitivity in colorectal cancer, with the reference allele correlating with better chemoradiation therapy response 5. Tumor-suppressive microRNAs (miR-125b-5p, miR-140-5p) regulate CORO2A expression in cancer cells, suggesting potential therapeutic targeting 4.