CPNE6 (copine 6) is a calcium-dependent phospholipid-binding protein with established neurological and emerging oncological significance. As a member of the copine family, CPNE6 binds phospholipid membranes in a calcium-dependent manner and is predominantly expressed in brain tissue, localizing to neuronal dendrites as evidenced by colocalization with the dendritic marker MAP2 1. The protein plays a functional role in calcium-mediated intracellular processes and dendrite extension. Abnormally elevated CPNE6 expression characterizes refractory epilepsy pathology. CPNE6 levels increase remarkably in both epileptic patients and chr14 pilocarpine-induced epileptic rat models 1, and increased interaction between CPNE6 and adenylate kinase 5 occurs in epileptic tissue 2, suggesting CPNE6 dysfunction contributes to seizure pathogenesis. Beyond neurology, CPNE6 shows disease relevance in cancer contexts. It was identified as a prognostic biomarker candidate in prostate cancer gene signature studies 3, glioblastoma molecular profiling 4, and triple-negative breast cancer hypoxia response pathways 5. CPNE6 also appears as a potential host interaction partner for chikungunya virus non-structural protein 2 6 and was identified as a candidate gene in intellectual disability genomic studies 7. These findings suggest CPNE6 participates in broader cellular processes beyond canonical neuronal functions, potentially including immune responses and viral pathogenesis.