CPNE7 (copine 7) is a calcium-dependent phospholipid-binding protein that plays diverse roles in cellular processes and disease pathogenesis. In colorectal cancer, CPNE7 functions as an oncogene, being highly expressed in CRC tissues and correlating with poor prognosis 12. Mechanistically, CPNE7 promotes tumorigenesis by interacting with NONO to initiate ZFP42 transcription, thereby enhancing cancer cell proliferation and metastasis 1. CPNE7 also contributes to chemotherapy resistance by downregulating ATG9B expression and affecting autophagy pathways, with CPNE7 depletion sensitizing CRC cells to 5-fluorouracil treatment 3. Beyond cancer, CPNE7 regulates amyloidogenesis in Alzheimer's disease through a CAP1-dependent mechanism that controls ADAM10 translation, reducing amyloid beta levels 4. In dental and periodontal tissues, CPNE7 promotes osteogenic differentiation through NF-κB pathway modulation 5 and facilitates periodontal ligament regeneration via TAU-mediated cytoskeleton reorganization and cementum attachment protein regulation 6. Clinical applications include a CPNE7-derived peptide (selcopintide) showing promise for treating dentin hypersensitivity by inducing physiologic dentin regeneration 7. These findings demonstrate CPNE7's multifaceted roles in cellular regulation, disease progression, and therapeutic potential.