GDPD4 is a glycerophosphodiester phosphodiesterase domain-containing protein localized to the plasma membrane with GPI anchor phospholipase C activity and glycerophosphodiester phosphodiesterase activity. Based on limited published evidence, GDPD4 is not essential for male fertility, as Gdpd4 knockout mice remain fertile 1. A rare variant in GDPD4 was identified in exome sequencing of a Thai family with obesity and may contribute to complex metabolic traits 2.