ABHD11 encodes a mitochondrial α/β-hydrolase domain-containing protein that serves multiple critical functions in cellular metabolism. The protein maintains the catalytic function of the α-ketoglutarate dehydrogenase (α-KGDH) complex in the TCA cycle by removing glutaryl adducts from lipoate, an essential fatty acid modification required for TCA cycle function 1. This deglutarylation activity prevents the accumulation of glutaryl-lipoyl adducts that would otherwise compromise mitochondrial metabolism 1. ABHD11 also functions as a lipid metabolism regulator, catalyzing diacylglycerol hydrolysis with substrate preference for 1,2-diacyl-sn-glycerols over 1,3-diacyl-sn-glycerols. In T-cell biology, ABHD11 plays a crucial role in immune regulation. Pharmacological inhibition of ABHD11 reduces cytokine production in human and mouse T-cells by increasing 24,25-epoxycholesterol biosynthesis and activating liver X receptor (LXR), which arises from TCA cycle compromise 23. This anti-inflammatory effect has therapeutic potential, as ABHD11 inhibition delays diabetes onset in murine autoimmune models 3. The protein's expression in CD4+ T-cells correlates with remission status in rheumatoid arthritis, highlighting its clinical relevance in autoimmune diseases 23.