ZNF202 is a transcriptional repressor that functions as a key regulator of lipid metabolism and HDL homeostasis 1. The protein contains a SCAN domain mediating protein dimerization and a Krüppel-associated box (KRAB) domain that recruits the corepressor KAP1 to inhibit gene transcription 2. ZNF202 binds to GnT repeats and other promoter elements in genes regulating lipid efflux and HDL metabolism, including ABCA1, ABCG1, apolipoprotein E, and lipoprotein lipase 2, 3. Expression of ZNF202 inversely correlates with its target genes; downregulation during macrophage differentiation permits ABCA1 and ABCG1 upregulation, enhancing cholesterol efflux 3. Clinically, ZNF202 is relevant to hypoalphalipoproteinemia susceptibility, as it is located within a disease susceptibility locus at chromosome 11 2. Overexpression of ZNF202 reduces HDL-mediated lipid efflux in macrophages and prevents cholesterol-responsive gene induction 2. Recent studies indicate ZNF202 participates in macrophage cholesterol homeostasis regulation through indirect effects on ABC transporter expression 4. ZNF202 represents a potential therapeutic target for lipid disorders including atherosclerosis and metabolic syndrome 1.