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GeneE
1 sources retrieved Β· Most recent: April 2026 Β· Index updated 14 days ago
β“˜GeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
ZNF670
zinc finger protein 670
Chromosome 1 Β· 1q44
NCBI Gene: 93474Ensembl: ENSG00000277462.3HGNC: HGNC:28167UniProt: Q9BS34
23PubMed Papers
8Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLE
Transcription Factor
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
protein bindinglipid metabolic processnucleusRNA polymerase II cis-regulatory region sequence-specific DNA bindingneurodegenerative diseasefemur fracturemedulloblastomaproliferative vitreoretinopathy
✦AI Summary

Based on limited published evidence, ZNF670 is a zinc finger protein predicted to function as a DNA-binding transcription factor regulating RNA polymerase II-mediated transcription. UniProt annotations indicate involvement in transcriptional regulation, with demonstrated DNA-binding capacity at cis-regulatory regions and association with lipid metabolic processes. The gene is localized to the nucleus and exhibits protein-binding activity. A breast cancer profiling study identified a lncRNA region (ZNF670-ZNF695) as significantly upregulated in tumor tissues 1, suggesting potential involvement in cancer-related gene expression networks, though direct functional characterization of ZNF670 itself remains limited.

Sources cited
1
ZNF670-ZNF695 lncRNA region identified as significantly upregulated in breast cancer tissue samples
PMID: 33037712
⚠Limited data available β€” This gene has 1 indexed publication. Summary and analysis may be incomplete.
Disease Associationsβ“˜8
neurodegenerative diseaseOpen Targets
0.28Weak
femur fractureOpen Targets
0.13Weak
medulloblastomaOpen Targets
0.02Suggestive
proliferative vitreoretinopathyOpen Targets
0.01Suggestive
primitive neuroectodermal tumorOpen Targets
0.01Suggestive
breast cancerOpen Targets
0.00Suggestive
neoplasmOpen Targets
0.00Suggestive
lymphomaOpen Targets
0.00Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
ZNF202Shared pathway100%FAM135BShared pathway100%PLCXD1Shared pathway100%FAM135AShared pathway100%ABHD11Shared pathway100%PLCXD3Shared pathway100%
Tissue Expression6 tissues
Brain
100%
Ovary
61%
Heart
60%
Liver
54%
Lung
45%
Bone Marrow
42%
Gene Interaction Network
Click a node to explore
ZNF670ZNF202FAM135BPLCXD1FAM135AABHD11PLCXD3
PROTEIN STRUCTURE
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AlphaFoldAI-predicted Β· UniProt Q9BS34
View on AlphaFold β†—
Constraintβ“˜
LOEUFβ“˜
1.15LoF Tolerant
pLIβ“˜
0.03Tolerant
Observed/Expected LoF0.61 [0.35–1.15]
RankingsWhere ZNF670 stands among ~20K protein-coding genes
  • #13,593of 20,598
    Most Researched23
  • #11,937of 17,882
    Most Constrained (LOEUF)1.15
Genes detectedZNF670
Sources retrieved1 papers
Response timeβ€”
πŸ“„ Sources
1
1
Profiling of specific long non-coding RNA signatures identifies ST8SIA6-AS1 AS a novel target for breast cancer.
PMID: 33037712
J Gene Med Β· 2021
1.00