PLCXD1 (phosphatidylinositol-specific phospholipase C X domain containing 1) is a phosphoric diester hydrolase located on the X/Y pseudoautosomal regions 1. The gene encodes a phosphatidylinositol-specific phospholipase C (PI-PLC) that cleaves membrane-bound proteins. In myalgic encephalomyelitis (ME), PLCXD1 expression is significantly elevated, correlating with enhanced cleavage of membrane-bound SMPDL3B and immune dysregulation; notably, PLCXD1 shows sex-specific regulation influenced by estrogen 2. PLCXD1 functions as a biomarker in sepsis pathophysiology, with molecular docking studies demonstrating strong binding affinity to baicalein, suggesting it may be targeted therapeutically to reduce inflammatory endothelial cell dysfunction 3. As a microRNA target, PLCXD1 is regulated by miR-575 and miR-1225-5p in breast cancer, where its modulation affects cell growth and motility 4. The gene's pseudoautosomal location is clinically relevant in sex chromosome X|Y; haploinsufficiency or aberrations in PLCXD1-containing regions contribute to spermatogenic failure and infertility phenotypes 5. Additionally, PLCXD1 demonstrates altered expression in ischemic stroke, implicating it in angiogenesis and potentially explaining sex differences in stroke pathology 6. As a tumor-suppressor candidate, PLCXD1 exhibits methylation and deletion in melanoma, with growth-suppressive properties 7.