Based on limited published evidence, PLCXD2 is a phospholipase C family member containing an X domain with phosphoric diester hydrolase activity. PLCXD2 functions as a constitutively active signaling component within a postsynaptic GPR158-PLCXD2 complex that regulates spine apparatus abundance and dendritic spine maturation 1. In the absence of GPR158-mediated inhibition, unrestrained PLCXD2 activity impedes postsynaptic development and dendritic spine structural/functional maturation 1. Additionally, a PLCXD2 intronic polymorphism (rs2399395) was identified as associated with esophageal squamous cell carcinoma risk in genome-wide association studies 2.