1 sources retrieved · Most recent: April 2026 · Index updated 15 days ago
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23PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
protein bindingstore-operated calcium entrycalcium ion bindingAbnormality of the skeletal systemcoronary artery diseaseFuchs endothelial corneal dystrophybreast cancer
CRACR2B is a calcium release activated channel regulator that plays a role in store-operated Ca2+ entry (SOCE), a fundamental mechanism for calcium signaling in cells. Based on limited published evidence, CRACR2B expression is altered in the subfornical organ following early postnatal overnutrition in rats, suggesting potential involvement in metabolic homeostasis regulation 1. The protein functions through calcium binding and protein-protein interactions to modulate store-operated calcium entry.
1
CRACR2B expression is significantly altered in the subfornical organ in response to early postnatal overnutrition, implying a role in homeostatic regulation
PMID: 30135952⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.
Abnormality of the skeletal systemOpen Targets
coronary artery diseaseOpen Targets
Fuchs endothelial corneal dystrophyOpen Targets
breast cancerOpen Targets
Barrett's esophagusOpen Targets
esophageal adenocarcinomaOpen Targets
posterior cortical atrophyOpen Targets
rheumatoid arthritisOpen Targets
chronic obstructive pulmonary diseaseOpen Targets
prostate adenocarcinomaOpen Targets
Sjogren syndromeOpen Targets
overnutritionOpen Targets
pancreatic ductal adenocarcinomaOpen Targets
relapsing-remitting multiple sclerosisOpen Targets
No pathogenic variants reported on ClinVar for this gene.