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GeneE
10 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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SRL
sarcalumenin
Chromosome 16 · 16p13.3
NCBI Gene: 6345Ensembl: ENSG00000185739.14HGNC: HGNC:11295UniProt: B3KPP4
10PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
store-operated calcium entryGTP bindingsarcoplasmic reticulum membranesarcoplasmic reticulum lumenatrial fibrillationhypertrophic cardiomyopathybenign prostatic hyperplasiaresponse to xenobiotic stimulus
✦AI Summary

I cannot provide an accurate gene function summary for SRL (sarcalumenin) based on the provided abstracts. While the NCBI annotation indicates sarcalumenin functions in store-operated calcium entry, none of the PubMed abstracts provided contain information about this protein. The abstracts discuss unrelated topics: sleep-related laryngospasm (1), ricin's effects on ribosomal RNA loops (2), oxysterols in clinical applications (3), mTOR inhibitor monitoring (4), sirolimus-induced angioedema (5), microRNA-22 metabolism (6), lectins from dietary sources (7), and pegvisomant in acromegaly treatment (8). Most abstracts use 'SRL' as an acronym for entirely different entities (sirolimus, sarcin-ricin loop, or Sclerotium rolfsii lectin), not sarcalumenin. To provide an evidence-based summary of sarcalumenin's function, structure, mechanism in calcium signaling, and disease relevance, abstracts specifically studying the sarcalumenin protein would be required.

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsⓘ20
atrial fibrillationOpen Targets
0.36Weak
hypertrophic cardiomyopathyOpen Targets
0.31Weak
benign prostatic hyperplasiaOpen Targets
0.30Weak
response to xenobiotic stimulusOpen Targets
0.28Weak
hypertensionOpen Targets
0.27Weak
neurodegenerative diseaseOpen Targets
0.27Weak
mixed connective tissue diseaseOpen Targets
0.26Weak
Umbilical herniaOpen Targets
0.23Weak
atrial flutterOpen Targets
0.14Weak
Thomsen and Becker diseaseOpen Targets
0.04Suggestive
autosomal recessive limb-girdle muscular dystrophy type 2LOpen Targets
0.04Suggestive
neoplasmOpen Targets
0.04Suggestive
Ascher syndromeOpen Targets
0.04Suggestive
Autosomal dominant limb-girdle muscular dystrophy type 1DOpen Targets
0.03Suggestive
Varicose veinsOpen Targets
0.03Suggestive
distal myopathyOpen Targets
0.03Suggestive
paramyotonia congenita of Von EulenburgOpen Targets
0.03Suggestive
prostate carcinomaOpen Targets
0.03Suggestive
hepatocellular carcinomaOpen Targets
0.03Suggestive
infectionOpen Targets
0.02Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
STIMATEShared pathway100%CRACR2BShared pathway100%RYR1Protein interaction94%ATP2A1Protein interaction71%CASQ1Protein interaction71%ORAI2Shared pathway50%
Tissue Expression6 tissues
Heart
100%
Brain
1%
Lung
0%
Ovary
0%
Liver
0%
Bone Marrow
0%
Gene Interaction Network
Click a node to explore
SRLSTIMATECRACR2BRYR1ATP2A1CASQ1ORAI2
PROTEIN STRUCTURE
Preparing viewer…
AlphaFoldAI-predicted · UniProt Q86TD4
View on AlphaFold ↗
Constraintⓘ
LOEUFⓘ
0.83LoF Tolerant
pLIⓘ
0.00Tolerant
Observed/Expected LoF0.58 [0.41–0.83]
RankingsWhere SRL stands among ~20K protein-coding genes
  • #17,183of 20,598
    Most Researched10
  • #7,089of 17,882
    Most Constrained (LOEUF)0.83
Genes detectedSRL
Sources retrieved10 papers
Response time—
📄 Sources
10▼
1
Laryngopharyngeal reflux induced sleep-related laryngospasm.
PMID: 35099721
Ir J Med Sci · 2023
1.00
2
How Ricin Damages the Ribosome.
PMID: 31035546
Toxins (Basel) · 2019
0.90
3
Oxysterols: From redox bench to industry.
PMID: 34968886
Redox Biol · 2022
0.80
4
Pharmacodynamic Monitoring of mTOR Inhibitors.
PMID: 30883509
Ther Drug Monit · 2019
0.70
5
Sirolimus-induced angioedema.
PMID: 15147436
Am J Transplant · 2004
0.60