CRH (corticotropin-releasing hormone) is a neuropeptide hormone that serves as the primary regulator of the hypothalamic-pituitary-adrenal (HPA) axis stress response system 1. As the main coordinator of adaptive responses to stressors, CRH stimulates corticotropin secretion from the anterior pituitary, ultimately triggering glucocorticoid release 1. Beyond its endocrine function, CRH acts as a neuromodulator, activating CRH receptors on hippocampal neurons to influence synaptic efficacy and cognition; however, pathological CRH levels contribute to neuronal death 2. CRH modulates multiple physiological systems: it inhibits appetite and reproductive function while activating thermogenesis and the dopaminergic reward system 1. CRH also exerts bidirectional sleep regulation through reciprocal interactions with growth hormone-releasing hormone 3. Locally, endometrial and placental CRH regulate embryo implantation and maternal immune tolerance through Fas ligand modulation 4. CRH receptors are involved in female reproductive axis regulation and trigger parturition 5. Dysregulated CRH signaling associates with vitiligo susceptibility through CRH-R1 polymorphisms 6 and contributes to obstetrical complications including preeclampsia and preterm delivery 5. CRH antagonists show therapeutic potential for melancholic depression and anxiety 1.